Magnetic Targeted Delivery of Dexamethasone Acetate Across the Round Window Membrane in Guinea Pigs
نویسندگان
چکیده
منابع مشابه
Quantitative anatomy of the round window and cochlear aqueduct in guinea pigs.
In order to analyze the entry of solutes through the round window membrane, a quantitative description of round window anatomy in relationship to scala tympani is required. High-resolution magnetic resonance microscopy was used to visualize the fluid spaces and tissues of the inner ear in three dimensions in isolated, fixed specimens from guinea pigs. Each specimen was represented as consecutiv...
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Cell-penetrating peptides (CPPs) are short sequences of amino acids that facilitate the penetration of conjugated cargoes across mammalian cell membranes, and as such, they may provide a safe and effective method for drug delivery to the inner ear. Simple polyarginine peptides have been shown to induce significantly higher cell penetration rates among CPPs. Herein, we show that a peptide consis...
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This study evaluated the histopathologic changes in the round window niche. , and membrane in cases of chronic suppurative otitis media. The pathologic process was found in all subjects. Fibrocystic or fibrous tissue was most commonly seen, while active granulation was less developed. The round window membrane was thicker and inflamed throughout its layers. Inflammatory invasion of the inne...
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Establishing efficient methods for local administration of drugs to the inner ear has great clinical relevance for the management of inner ear disorders. However, the administration route remains a critical issue. The most feasible approach for a non invasive drug delivery to the inner ear is application of medication to the middle ear cavity on the promise that it will diffuse through the thin...
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Background: Several therapeutic effects including anti-asthma and dyspnea have been described for Plantago lanceolata. In the present study the antitussive effect of this plant was evaluated. Methods: The antitussive effects of aerosols of two different concentrations of Soxhlet and macerated ethanolic extracts, codeine and saline were tested by counting the number of coughs produced due to aer...
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ژورنال
عنوان ژورنال: Otology & Neurotology
سال: 2013
ISSN: 1531-7129
DOI: 10.1097/mao.0b013e318277a40e